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Buy the book at www.EndMalariaDay.com and save a life.

It isn't very often that a book has the power to save a life. Yes, good books can improve lives, shape lives, even change lives. But when was the last time a book literally helped save a life? If you're reading this page, the answer is right now.

This year, The Domino Project set out to change the future of publishing, and now it’s out to change the future of philanthropy.

The project’s latest release, by author Michael Bungay Stanier of Box of Crayons fame, is out to tackle one of our civilization’s grimmest epidemics: malaria. (And if the gravity of the issue still hasn’t stopped you dead in your tracks — like, for instance, the fact that a child dies of malaria every 45 seconds — watch Bill Gates’ 2009 TED talk.)

End Malaria: Bold Innovation, Limitless Generosity, and the Opportunity to Save a Life, released on End Malaria Day today, is a fantastic anthology that will save lives — by helping you be better, smarter, more efficient at your job.

The book features essays, tips and insights on great work by 62 leading writers and thinkers — including everyones' favourites Sir Ken Robinson, Brené Brown, Kevin Kelly, Scott Belsky, Barry Schwartz, Daniel Pink, Derek Sivers and more — with $20 out of every $25 book sale (that’s 80%, for the mathematically challenged) going to Malaria No More to buy mosquito nets for Africa, still the most effective malaria prevention method. (For comparison purposes, most product-based charitable contributions are in the 5-10% range.)

H1N1: BMJ Medical Experts Debunk Tamiflu effectiveness and usage

The ongoing investigation of antiviral drugs and their unproven effectivenesss continues.

UK medical experts from the British Medical Journal (BMJ) are questioning the effectiveness of antiviral drug Tamiflu commonly used against the swine flu virus spreading across the globe, according to a study reported in Britain Tuesday.

An investigation by the British Medical Journal acknowledges that the drug oseltamivir, which trades as Tamiflu, has "a very modest effect in reducing flu symptoms and infectivity in otherwise healthy adults."

But "researchers say there is insufficient published data to know if oseltamivir reduces complications in otherwise healthy adults," the media groups said in a joint statement.

The use of flu drugs like oseltamivir has increased dramatically since the A(H1N1), or swine flu, pandemic began in April 2009, with government rushing to stockpile treatments while persuading people to have vaccinations.

The global death toll since the virus was uncovered in April approached 8,770 in early December, with confirmed infections in 207 countries, according to World Health Organisation figures.

Claims about the effectiveness of drugs like Tamiflu against flu complications have been a key factor in governments' choosing to spend millions of dollars to hoard them, the British Medical Journal said.

The British government has spent about 500 million pounds (813.9 million dollars) on such drugs, they said.

But research on the drugs by scientists from Australia's Bond University was hampered by a "paucity of good data" available from Swiss pharmaceutical giant Roche that produces oseltamivir.

"As a result, they conclude that they have no confidence in claims that oseltamivir reduces the risk of complications of influenza in otherwise healthy adults, and believe it should not be used in routine control of seasonal influenza."

The researchers called on governments to set up studies to monitor the safety of drugs like Tamiflu, which are called neuraminidase inhibitors.

A team from the University of Birmingham concluded meanwhile that oseltamivir may reduce the risk of pneumonia in otherwise healthy people who contract flu.

"However, the absolute benefit is small, and side effects and safety should also be considered," the statement said.

Professor Nick Freemantle from the University of Birmingham said he saw "very little evidence to support the widespread use of oseltamivir in the otherwise healthy population who are developing signs of influenza-like illness."

"We have remarkably few resources in this country to spend on pharmaceuticals on health and it's surprising to see such widespread use of oseltamivir," he said.

British Medical Journal editor-in-chief Fiona Godlee warned that the review left unresolved important questions about effectiveness of the drugs.

"Governments around the world have spent billions of pounds on a drug that the scientific community now finds itself unable to judge," she said.

Roche has estimated sales of 1.6 billion pounds this year alone from the drug, the statement said.

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